Ginseng and Astragalus as Natural Vaccine Adjuvants ?

It appears that Ginseng and Astragalus BOTH enhance immune response in H5N1, and potentially could be used as Natural Vaccine Adjuvants (in comparison current adjuvants used in some vaccines are Aluminum, and Monophosphoryl Lipid A.) 

Natural Adjuvants in Vaccines ?

Natural Adjuvants in Vaccines ?

Vaccination with Astragalus and Ginseng Polysaccharides Improves Immune Response of Chickens against H5N1 Avian Influenza Virus.


To determine the effect of astragalus and ginseng polysaccharides (APS, GPS) on immune response and improvement of H5N1 vaccine, 360-day-old broilers were randomly divided into 8 groups of 45 chicks, comprising APS groups (1-3); GPS groups (4-6); vaccine group (7); and blank control (8) (without polysaccharide and vaccine). From day 12 after hatch groups 1-3 were given APS and groups 4-6 with GPS both at 100, 200, and 400?(mg/kg), respectively. At day 15 after hatch, groups 1-7 were vaccinated with 0.3?mL H5N1 vaccine subcutaneously; daily weight gain (DWG) and serum Ig antibody (by HI-test) were measured on 3, 7, 14, and 28 days after vaccination. Serum antibody titers and expression of cytokines (IL-2, IL-10, I FN-?, and TNF) were determined by ELISA and RT-PCR. Results revealed that all the polysaccharide groups were numerically increased in antibody levels and the expression of cytokines was significant (P < 0.05) in the APS and GPS groups compared to corresponding vaccine group and blank control. DWG was higher (P < 0.05) in 400?mg/kg APS groups than control groups. Thus oral supplements of GPS and APS have shown their potential in the improvement of immune response and could be used as adjuvant in a formulation of H5N1 vaccine.


Abdullahi AY, Kallon S, Yu X, Zhang Y, Li G. Vaccination with Astragalus and Ginseng Polysaccharides Improves Immune Response of Chickens against H5N1 Avian Influenza Virus. Biomed Res Int. 2016;2016:1510264. doi: 10.1155/2016/1510264. PubMed PMID: 27597953; PubMed Central PMCID: PMC5002477.


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