IP6 suppress Colorectal cancer cell proliferation

What is IP6?

IP6, also known as inositol hexophosphate or phytic acid, is a sugar molecule with six phosphate groups attached. It is composed of inositol (one of the B vitamins) bound with six molecules of phosphorous. IP6 was first identified in 1855, but has only recently been researched as a preventative and cure for cancer as well as heart and liver diseases, kidney stones, Parkinson’s disease, and more. It is also a powerful antioxidant, immune system enhancer, and booster of natural killer cells. Foods that are significant sources of IP6 include dried beans, whole grains, nuts, seeds, rice, wheat germ, corn and sesame.

Dr. Abulkalam Shamsuddin, a scientist at the University of Maryland School of medicine has been the pioneer researcher of IP6, beginning his work on the compound in the late 1980’s. He discovered the ability of IP6 to control the rate of abnormal cell division even when administered long after cancer was induced. He then proved that IP6 normalized the sugar production of cancerous cells, thereby altering the gene expression toward a more healthful state. This proven ability to change cancer cell physiology had major implications, since cancer cells that are well behaved have far less negative impact on health.


Inositol hexaphosphate  (IP6) suppresses colorectal cancer cell proliferation.


Colorectal cancer (CRC) is common worldwide, and most treatments for CRC have undesirable side effects. Many researchers have demonstrated that inositol hexaphosphate (IP6) has potent anticarcinogenic activity against CRC and no apparent toxicity to normal cells. However, the underlying mechanism is still unclear. In this study, we investigated the anticancer and anti-proliferative properties of IP6 in CRC and its possible mechanisms during this chemopreventive process. We examined the expression of genes related to the PI3K/Akt and Wnt pathways at the transcriptional and translational levels in a DMH-induced rat CRC model following IP6 administration. In addition, we also conducted cell proliferation analysis. The results demonstrated that IP6 could inhibit tumors, in terms of tumor incidence, number, weight and volume in DMH-induced rats. Additionally, Akt and c-Myc mRNA levels were significantly decreased. IP6was also shown to downregulate Akt, pAkt, pGSK-3?, and c-Myc protein expression and upregulate p?-catenin protein expression. Furthermore, tumor tissues from IP6-treated rats showed decreased proliferation. In conclusion, the anti-proliferative effect of IP6 may be related to crosstalk between the PI3K/Akt and Wnt pathways, revealing a potential mechanism of CRC inhibition by IP6 in our model.


Yu W, Liu C, Li X, Yang F, Cheng L, Liu C, Song Y. Inositol hexaphosphate suppresses colorectal cancer cell proliferation via the Akt/GSK-3?/?-catenin signaling cascade in a 1,2-dimethylhydrazine-induced rat model. Eur J Pharmacol. 2017 Mar 15. pii: S0014-2999(17)30161-9. doi: 10.1016/j.ejphar.2017.03.011. PubMed PMID: 28315345.


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